
Antidepressant withdrawal and the guideline gap
A 2022 systematic review found that 15 of 21 depression guidelines say to taper antidepressants gradually, and none say how. What that leaves prescribers holding.
Medication matters. Let's talk about it.
Prescriby Health is a provider-led tapering clinic. If you are on an antidepressant, a benzodiazepine, an opioid, a sleep medication, gabapentin or a stomach-acid medication and want to come off it, we write the plan, take over the prescribing, and support you all the way to your goal.

Start with what you are actually taking. Each page covers what the medication does, what long-term use can do, what withdrawal can feel like, and how we taper it.
Sertraline (Zoloft), escitalopram (Lexapro), venlafaxine (Effexor), duloxetine (Cymbalta), paroxetine (Paxil) and others.
Alprazolam (Xanax), clonazepam (Klonopin), lorazepam (Ativan), diazepam (Valium), temazepam (Restoril).
Oxycodone (OxyContin, Percocet), hydrocodone (Norco, Vicodin), tramadol (Ultram), morphine, fentanyl patches.
Zolpidem (Ambien), eszopiclone (Lunesta), zaleplon (Sonata).
Gabapentin (Neurontin, Gralise) and pregabalin (Lyrica).
Omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), lansoprazole (Prevacid).
A provider-led plan, adjusted as you go.
Contact us directly, or ask your doctor to refer you. You do not need a referral to start.
About an hour with a provider, going through your medication history, your health, and what you want to change.
A written, dose-by-dose schedule for your medication. We take over prescribing it while you taper, so refills are not a monthly negotiation.
Every one to four weeks, by telehealth or in person. If a step is too hard, we slow down.
Our outcomes speak for themselves. These figures come from Prescriby's dedicated tapering clinic in Iceland, run in 2024–2025 in partnership with Iceland's Ministry of Health. The US clinic in Maine uses the same care model; its own outcome data is not yet published.
Iceland clinic cohort, 2024–2025.
Iceland clinic cohort, 2024–2025.
Iceland clinic cohort, 2024–2025.
Tapering is not a side service here. It is the entire clinic.
The protocols, the app, the follow-up intervals and the providers are all built around reducing medication safely. It is what we do all day.
Some patients want off completely. Others want a lower dose they can live with. Both are real outcomes, and the plan is written to whichever one you choose.
While you taper, we manage the prescription for the medication being reduced — so you are not negotiating refills in the middle of a dose change.
After years on Oxynorm, my health had declined and I had very little energy. With Prescriby's structured tapering plan and daily tracking app, I felt supported throughout the process. The first weeks were tough, but with guidance from my Prescriby clinician I made steady progress. In just three months, I fully tapered off, far quicker than expected, and regained my health and energy. Prescriby made it possible.
When co-founder Kjartan Thorsson was working at the orthopedic surgery ward in Reykjavik, he noticed a troubling pattern: patients arrived for routine procedures — and many needed opioids prescribed on discharge, exposing them to significant risk of developing dependency. The resources to help them simply didn't exist.
Prescriby Health was born in 2020, and soon Johannes Torfason joined the team where the two founders formed a care model involving technology and specialized care, a model that made tapering treatments a realistic and reliable choice. They called it an "upstream" approach: where people could safely taper off medications that could be causing them harm.
Helping patients taper down after surgery or to get off medication they had been using for years, the model works. Iceland's Ministry of Health took notice and partnered with Prescriby for a nationwide rollout. Now, with proven outcomes and close to a thousand patients helped, Prescriby Health is bringing this approach to the United States, starting in South Portland, Maine.
Prescriby Health was established to address the growing need for safe medication tapering.
Conducted trials and workshops with patients and caregivers to refine our approach.
Achieved regulatory and compliance approvals for our care model.
Nationwide rollout of our tapering program across Iceland.
Secured seed funding to expand our mission.
Conducted clinical trial proving the care model — 88.2% success rate.
The US clinic opened on February 5, bringing the care model to Maine.
2x nominated Nordic Startup Awards (Iceland Nationals).
Finalists for Best Health Tech 2021, 2022, and 2023.
Founder of the Year 2021.
Fuller answers, and more of them, are on the program details page.
Because the reason it was prescribed may no longer apply, and long-term use of these medications can carry costs — on memory, balance, sleep, mood or the gut — that are only worth paying if the medication is still doing a job. A supervised taper is how you find out.
What it is not is a reason to stop on your own. Some of these medications are dangerous to stop abruptly.
Almost certainly not, in the clinical sense. Physical dependence means your body has adapted, so stopping abruptly causes withdrawal — that happens to people who followed every instruction perfectly. Addiction is a behavioral pattern of craving and loss of control. They are different problems with different treatment, and most of the people we see are dependent rather than addicted.
It depends on the medication, the dose, and how long you have been taking it. A post-surgical opioid taper is often weeks. Antidepressants, sleep medications and gabapentinoids usually take a few months. Benzodiazepines after long-term use take the longest. Your provider gives you a realistic estimate at intake.
No. Many of our patients contact us directly. Providers can also refer, and either way we coordinate with whoever manages the rest of your care.

A 2022 systematic review found that 15 of 21 depression guidelines say to taper antidepressants gradually, and none say how. What that leaves prescribers holding.

Dr. Jennifer Monti joins Dr. Lisa Belisle on Radio Maine to discuss thoughtful, evidence-based deprescribing — why medications that were once appropriate aren't always meant to stay part of a person's care forever.

Maine Startups Insider profiled Prescriby Health's journey from Reykjavik to South Portland — and why co-founder Dr. Kjartan Thorsson chose Maine for the company's first U.S. clinic.
Everything you tell us is handled under HIPAA — the intake and referral forms, the app, your taper record, and every message in between. Please keep protected health information out of the general contact form and use the secure forms instead.
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Tell us what you are taking and how long you have been taking it. We will tell you what a taper would involve, roughly how long it would take, and what it would cost.
Providers: you can refer a patient by fax, email, phone or our secure form, and we take on the tapering from there.